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February 26, 2026PLoS GeneticsOpen Access

Correction: DNAJB1-PRKACA fusion protein-regulated LINC00473 promotes tumor growth and alters mitochondrial fitness in fibrolamellar carcinoma

Rosanna K. Ma Pei-Yin Tsai Alaa R. Farghli Alexandria Shumway Matt Kanke John D. Gordan Taranjit S. Gujral Khashayar Vakili Manabu Nukaya Leila Noetzli Sean M. Ronnekleiv‐Kelly Wendy Broom Joeva J. Barrow Praveen Sethupathy

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Key Points

The aim is to clarify how the DNAJB1-PRKACA fusion protein affects LINC00473 and tumor behavior in fibrolamellar carcinoma.
Examination of the effects of the fusion protein on LINC00473 expression.
Analysis of tumor growth dynamics related to LINC00473.
Assessment of mitochondrial fitness alterations due to fusion protein regulation.
LINC00473 expression correlates with increased tumor growth.
Alterations in mitochondrial fitness were observed with the regulation of the fusion protein.

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Implication

Correction indicates LINC00473 promotes tumor growth in fibrolamellar carcinoma, suggesting potential targets for therapy.

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Cite This Study

Ma et al. (2026) studied this question.

synapsesocial.com/papers/69a3d6eaec16d51705d2daac https://doi.org/10.1371/journal.pgen.1012054

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1DNAJB1-PRKACA fusion protein-regulated LINC00473 promotes tumor growth and alters mitochondrial fitness in fibrolamellar carcinoma2024 · 13 citations
2Data from Increased Protein Kinase A Activity Induces Fibrolamellar Hepatocellular Carcinoma Features Independent of DNAJB12024
3Abstract 137: Increased activity of protein kinase A is sufficient to cause fibrolamellar carcinoma2024
4<i>DNAJB1–PRKACA</i> fusion kinase interacts with β-catenin and the liver regenerative response to drive fibrolamellar hepatocellular carcinomaCohort Study · 2017 · 160 citations
5Independent Multi-Cohort RNA-Seq Analysis Does Not Support Recurrent DNAJB1::PRKACA Fusion in Hepatoblastoma or Biliary Atresia. Comment on Fleifil et al. DNAJB1-PKAc Kinase Is Expressed in Young Patients with Pediatric Liver Cancers and Enhances Carcinogenic Pathways. Cancers 2025, 17, 83Original Research · 2026 · 1 citations

More related papers

Increased Protein Kinase A Activity Induces Fibrolamellar Hepatocellular Carcinoma Features Independent of DNAJB12024
Fusion DNAJB1::PRKACA in Non-Fibrolamellar Cancer Cases. Reply to Arif et al. Global Re-Analysis Confirms Absence of the DNAJB1::PRKACA Fusion in Hepatoblastoma. Comment on “Fleifil et al. DNAJB1-PKAc Kinase Is Expressed in Young Patients with Pediatric Liver Cancers and Enhances Carcinogenic Pathways. Cancers 2025, 17, 83”2026
Supplementary Data from Increased Protein Kinase A Activity Induces Fibrolamellar Hepatocellular Carcinoma Features Independent of DNAJB12024

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