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March 1, 2026HaematologicaOpen Access

Prognostic implications of myelodysplasia-related gene mutations in NPM1-mutated acute myeloid leukemia: a systematic review and meta-analysis

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Authors

YCYu-Sung ChangYLYi-Wei LeeCLChieh-Yu Liu

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Overview

Systematic review and meta-analysis reveals the impact of myelodysplasia-related gene mutations on survival in NPM1-mutated acute myeloid leukemia, suggesting significant prognostic implications.

Key Points

  • This review aims to clarify the prognostic significance of myelodysplasia-related gene mutations in NPM1-mutated acute myeloid leukemia.
  • Conducted a systematic review and meta-analysis adhering to PRISMA guidelines.
  • Searched databases including PubMed, Embase, and MEDLINE up to March 2025.
  • Included data from ten cohorts across nine studies, analyzing a total of 4,363 patients.
  • 15.0% of analyzed patients harbored co-occurring myelodysplasia-related gene mutations.
  • Among ELN-2022 intermediate risk patients, 8.3% had myelodysplasia-related gene mutations.
  • Presence of these mutations was associated with inferior overall survival (pooled HR 1.30; 95% CI 1.11-1.51).

Cite This Study

Chang et al. (2026) studied this question.

synapsesocial.com/papers/69a3d6eaec16d51705d2db0chttps://doi.org/10.3324/haematol.2025.288081
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prognostic impact of myelodysplasia-related gene mutations in FLT3-ITD-mutated acute myeloid leukemia2026 · 1 citations
  2. 2Impact of <i>NPM1</i> co-mutation on post-transplant outcomes in MRG-mutated AML.2026
  3. 3Prognostic impact of myelodysplasia-related gene mutations in ELN-2022 favorable-risk acute myeloid leukemia subtypes2026 · 1 citations
  4. 4Prognostic impact of co-occurring mutations in NPM1-mutated Acute Myeloid Leukemia2025
  5. 5Translating meta-analytic risk into absolute survival: Projection modeling of secondary-type mutations in ELN-favorable NPM1-mutated acute myeloid leukemia.2026