A case series finds increased infusion-related reactions in patients switching monoclonal antibodies, suggesting a need for better management.
This case series suggests that prior exposure to mAbs may predispose some patients to more pronounced IRRs when switched to another agent in the class. Larger observational studies are needed to establish the incidence, mechanisms, and best practices for prevention and management.
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Gopalakrishna et al. (2026) studied this question.
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