Clinical characteristics of osteonecrosis of the jaw related to denosumab: a 5-year retrospective cohort study

Q: What does this research mean for the field?

High-dose denosumab treatment is associated with poorer prognosis and more frequent recurrence of medication-related osteonecrosis of the jaw (MRONJ) compared to low-dose denosumab or bisphosphonate to denosumab transition therapy. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.NEUTRAL.

Keuk-Je Cho; Ming-Xu Jin; Prof. So-Young Choi; Tae-Geon Kwon

doi:10.5125/jkaoms.2026.52.1.18

February 27, 2026Journal of the Korean Association of Oral and Maxillofacial SurgeonsOpen Access

Clinical characteristics of osteonecrosis of the jaw related to denosumab: a 5-year retrospective cohort study

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Key Points

This study aims to investigate the clinical characteristics and outcomes of osteonecrosis of the jaw (ONJ) related to denosumab therapy over five years.
Retrospective cohort design analyzing patient records over five years.
Assessment of clinical characteristics related to osteonecrosis of the jaw.
Comparison between high-dose and low-dose denosumab treatment outcomes.
Patients on high-dose denosumab showed poorer prognosis and more frequent recurrence.
Earlier onset of ONJ was observed in the transition group from bisphosphonates to denosumab.
Cumulative duration of antiresorptive therapy was highlighted as a contributing factor.

Implication

Retrospective cohort study shows denosumab dosage affects outcomes in osteonecrosis of the jaw, suggesting careful management.

Discussion

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Cite This Study

Cho et al. (2026) studied this question.

synapsesocial.com/papers/69a3d79dec16d51705d2ddb8 https://doi.org/10.5125/jkaoms.2026.52.1.18

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Clinical characteristics of osteonecrosis of the jaw related to denosumab: a 5-year retrospective cohort study

Key Points

Implication

Discussion

Cite This Study

Clinical characteristics of osteonecrosis of the jaw related to denosumab: a 5-year retrospective cohort study

Key Points

Implication

Discussion

Cite This Study

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