What does this research mean for the field?

Iridium-catalyzed asymmetric alkylation enables the stereoselective construction of cis-cyclobutanes from bicyclo[1.1.0]butane-derived boronate complexes through 1,2-alkoxy migration. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

The study aims to explore 1,2-oxygen migration in boronate complexes for asymmetric catalysis, specifically targeting the formation of cis-cyclobutanes.

March 1, 2026Nature CommunicationsOpen Access

Catalytic asymmetric functionalization of bicyclo1.1.0butane boronic esters enabled by 1,2-oxygen migration

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Authors

XZXin-Yuan ZhuShanghaiTech University CJChong‐Lei JiShanghaiTech University TDTiange DongTechnische Universität Dresden

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Implication

Iridium-catalyzed alkylation enables stereoselective construction of cis-cyclobutanes, suggesting innovative pathways in catalysis.

Key Points

The study aims to explore 1,2-oxygen migration in boronate complexes for asymmetric catalysis, specifically targeting the formation of cis-cyclobutanes.
Developed an iridium-catalyzed asymmetric alkylation reaction.
Utilized bicyclo[1.1.0]butane-derived boronate complexes.
Investigated the mechanistic pathway of alkoxy migration.
Successfully achieved stereoselective construction of cis-cyclobutanes.
Demonstrated that 1,2-alkoxy migration proceeds stepwise with C–C bond formation.
Revealed higher energy barriers for 1,2-oxygen migration compared to competing pathways.

Cite This Study

Zhu et al. (2026) studied this question.

synapsesocial.com/papers/69a3d79dec16d51705d2dde7 https://doi.org/10.1038/s41467-026-69860-9

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Catalytic asymmetric functionalization of bicyclo1.1.0butane boronic esters enabled by 1,2-oxygen migration

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Implication

Key Points

Cite This Study

Catalytic asymmetric functionalization of bicyclo1.1.0butane boronic esters enabled by 1,2-oxygen migration

Discussion

Member takes

Implication

Key Points

Cite This Study

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