What question did this study set out to answer?

This research aims to explore the interactions between host and microbiome during the critical weaning transition in piglets.

Multi-omics integrated approach reveals host-microbiome interactions in the adaptive mechanisms of weaning piglets

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Investigating host-microbiome interactions and adaptive mechanisms in weaning piglets, indicating important health implications.

This research aims to explore the interactions between host and microbiome during the critical weaning transition in piglets.
Collection of fecal and tissue samples at different weaning stages (W0, W7, W14)
Analysis of ileal microbiota and microbial-derived metabolites
Transcriptomic profiling to identify differentially expressed genes
Morphological examination of ileum for villus architecture changes
Fecal microbiota showed greater stability at W14 with increased fiber-degrading bacteria
Ileal microbiota adapted with enhanced populations of lactobacillus and clostridium
Morphological changes in ileal tissue indicated improved gut health with increased villus area
Identification of 506 differentially expressed genes linked to immune pathways during adaptation

Lee et al. (2026) studied this question.

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