Activation of the Integrin αV-YAP-CTGF Axis in Liver Sinusoidal Endothelial Cells Promotes Liver Fibrogenesis, Leading to Portal Hypertension and Liver Carcinogenesis in Congestive Hepatopathy | Synapse
March 1, 2026Open Access
Activation of the Integrin αV-YAP-CTGF Axis in Liver Sinusoidal Endothelial Cells Promotes Liver Fibrogenesis, Leading to Portal Hypertension and Liver Carcinogenesis in Congestive Hepatopathy
Key Points
The research aims to explore how the activation of the integrin αV-YAP-CTGF axis contributes to liver fibrogenesis in congestive hepatopathy.
Investigated the role of CTGF in liver sinusoidal endothelial cells (LSECs).
Analyzed the integrin αV-YAP-CTGF signaling pathway.
Assessed implications for liver fibrogenesis and related conditions.
CTGF induction was found to have an upstream role in liver fibrogenesis.
Activation of the integrin αV-YAP-CTGF axis links to portal hypertension and liver cancer.
The findings indicate potential therapeutic targeting of this pathway in congestive hepatopathy.
Abstract
CTGF induction in LSECs may play an upstream role in the fibrogenesis of CH. The integrin αV-YAP-CTGF axis in LSECs could be a potential therapeutic target for CH.