Matching heterogeneous cohorts by projected principal components reveals two novel Alzheimer's disease-associated genes in the Hispanic population.

Key Points

• The research aims to identify novel genes associated with Alzheimer's disease by matching heterogeneous cohorts.
• Matched subjects from large biobanks and small cohorts using projected principal components.
• Analyzed genetic data to find associations with Alzheimer's disease.
• Identified two novel genes associated with Alzheimer's disease specifically in the Hispanic population.
• Demonstrated effectiveness of cohort matching for uncovering new genetic findings.