What question did this study set out to answer?

This research aims to determine how binding of LFA-1 to ICAM-1, -2, and -3 affects cytokine secretion and T cell proliferation.

March 1, 2026Journal of Marine Fisheries

Co-stimulation of T cells results in distinct IL-10 and TNF-alpha cytokine profiles dependent on binding to ICAM-1, ICAM-2 or ICAM-3

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Authors

DBD A BleijsRadboud University Nijmegen RWR de Waal-Malefyt CFC G Figdor

Discussion

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Implication

Demonstrates different cytokine profiles resulting from T cell co-stimulation via ICAM-1, -2, or -3, indicating distinct functional roles for each ligand.

Key Points

This research aims to determine how binding of LFA-1 to ICAM-1, -2, and -3 affects cytokine secretion and T cell proliferation.
Utilized LFA-1 adhesion molecule to assess T cell proliferation in response to anti-CD3 monoclonal antibodies.
Compared cytokine secretion levels when T cells were co-stimulated with ICAM-1, ICAM-2, or ICAM-3.
Measured levels of multiple cytokines including IL-10, TNF-alpha, and other T helper cytokines.
T cell proliferation varied with ligand, showing high on ICAM-1, intermediate on ICAM-2, and weak on ICAM-3.
IL-10 was significantly higher when LFA-1 co-stimulated with ICAM-1 compared to ICAM-2 and ICAM-3.
ICAM-2 and ICAM-3 led to higher TNF-alpha production despite lower T cell proliferation.

Cite This Study

Bleijs et al. (1999) studied this question.

synapsesocial.com/papers/69a3d7dfec16d51705d2e4ac https://doi.org/10.1002/(sici)1521-4141(199907)29:07

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March 1, 2026Journal of Marine Fisheries

Co-stimulation of T cells results in distinct IL-10 and TNF-alpha cytokine profiles dependent on binding to ICAM-1, ICAM-2 or ICAM-3

View Full Paper

Ask AI

Bookmark

Authors

DBD A BleijsRadboud University Nijmegen RWR de Waal-Malefyt CFC G Figdor

Discussion

Member takes

Implication

Demonstrates different cytokine profiles resulting from T cell co-stimulation via ICAM-1, -2, or -3, indicating distinct functional roles for each ligand.

Key Points

This research aims to determine how binding of LFA-1 to ICAM-1, -2, and -3 affects cytokine secretion and T cell proliferation.
Utilized LFA-1 adhesion molecule to assess T cell proliferation in response to anti-CD3 monoclonal antibodies.
Compared cytokine secretion levels when T cells were co-stimulated with ICAM-1, ICAM-2, or ICAM-3.
Measured levels of multiple cytokines including IL-10, TNF-alpha, and other T helper cytokines.
T cell proliferation varied with ligand, showing high on ICAM-1, intermediate on ICAM-2, and weak on ICAM-3.
IL-10 was significantly higher when LFA-1 co-stimulated with ICAM-1 compared to ICAM-2 and ICAM-3.
ICAM-2 and ICAM-3 led to higher TNF-alpha production despite lower T cell proliferation.

Cite This Study

Bleijs et al. (1999) studied this question.

synapsesocial.com/papers/69a3d7dfec16d51705d2e4ac https://doi.org/10.1002/(sici)1521-4141(199907)29:07

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