Sex Differences in Liver Cancer Mortality Trends in the US: Role of Cancer Type, Aetiology, and Birth Cohort.

Key Points

• To explore sex differences in liver cancer mortality trends in the US and the contributing factors such as cancer type and birth cohort.
• Analyzed liver cancer mortality data in the US by sex and age groups
• Examined etiologies of hepatocellular carcinoma and intrahepatic cholangiocarcinoma
• Investigated trends in mortality rates over different birth cohorts
• Mortality rates for liver cancer are declining in men
• Mortality rates in women are increasing, particularly due to intrahepatic cholangiocarcinoma
• Changing etiologies of liver cancer show significant trends based on sex and birth cohort