Abstract Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is the most recently defined distinct demyelinating disorder of the central nervous system which has heterogeneous clinical manifestations. Here, we present the case of isolated bilateral optic neuritis (ON) in an 11-year-old female who presented with bilateral acute and progressive loss of vision with pain on ocular movement over the past 2 days following mild fever. Neuroimaging revealed the features suggestive of isolated ON more in favor of MOGAD. Spine imaging was within the normal limits. She was seronegative for aquaporin-4 antibodies but tested positive for myelin oligodendrocyte glycoprotein antibodies. Her visual acuity recovered completely with systemic steroids but with residual functional and structural loss on visual fields and optical coherence tomography, respectively.
Singh et al. (Thu,) studied this question.