Effect of neuromuscular electrical stimulation associated with therapeutic exercise on pain, function, and strength of people with knee osteoarthritis: a systematic review with meta-analysis of randomized clinical trials with GRADE recommendations.

Q: What does this research mean for the field?

Neuromuscular electrical stimulation (NMES) combined with therapeutic exercise may modestly improve long-term pain and mobility in individuals with knee osteoarthritis. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

Andressa Costa da Silva; Geovanna Cândido Rafael; Rayane Quintão Castro; Priscila Monteiro Veras; Cyntia Pace Schmitz Corrêa; Jennifer Granja Peixoto; Fabiana Roberta Nunes Carnaúba; Marco Antônio Cavalcanti Garcia; Carla Malaguti; Diogo Carvalho Felí­cio; Diogo Simões Fonseca

doi:10.1080/09638288.2026.2633271

February 26, 2026

Effect of neuromuscular electrical stimulation associated with therapeutic exercise on pain, function, and strength of people with knee osteoarthritis: a systematic review with meta-analysis of randomized clinical trials with GRADE recommendations.

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Key Points

The aim is to assess the effectiveness of neuromuscular electrical stimulation combined with therapeutic exercise on pain, function, and strength in knee osteoarthritis.
Systematic review of randomized clinical trials
Analysis included studies utilizing neuromuscular electrical stimulation and therapeutic exercise
GRADE recommendations evaluated the quality of evidence
NMES combined with exercise may lead to modest long-term improvements in pain
Improvements in mobility were also reported, although confidence in evidence is very low

Implication

Systematic review shows NMES combined with exercise may improve pain and mobility in knee osteoarthritis, indicating modest benefits.

Abstract

NMES + exercise may modestly improve long-term pain and mobility in KOA, though evidence certainty is very low.

Discussion

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Cite This Study

Silva et al. (2026) studied this question.

synapsesocial.com/papers/69a3d811ec16d51705d2e934 https://doi.org/10.1080/09638288.2026.2633271

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Effect of neuromuscular electrical stimulation associated with therapeutic exercise on pain, function, and strength of people with knee osteoarthritis: a systematic review with meta-analysis of randomized clinical trials with GRADE recommendations.

Key Points

Implication

Abstract

Discussion

Cite This Study

Effect of neuromuscular electrical stimulation associated with therapeutic exercise on pain, function, and strength of people with knee osteoarthritis: a systematic review with meta-analysis of randomized clinical trials with GRADE recommendations.

Key Points

Implication

Abstract

Discussion

Cite This Study

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