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March 1, 2026

Senolytics and exercise: Dual modalities for rejuvenating muscle.

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Authors

ZYZeynep Elif YeşilyurtCQCe QiUOUchenna Okpechi

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Overview

This review evaluates senolytics and exercise for reversing muscle aging and improving function in older individuals, suggesting dual benefits.

Key Points

  • To explore the role of senolytics in rejuvenating heart and skeletal muscle by targeting cellular senescence.
  • Review of existing studies on senolytics and exercise effects on muscle and heart health.
  • Analysis of cellular mechanisms related to tissue homeostasis.
  • Evaluation of current clinical data on senolytics and their impact on aging.
  • Senolytics demonstrated improved regeneration and function in skeletal muscle.
  • Exercise showed parallel effects on cellular senescence, exhibiting senolytic properties.
  • Combined approach suggests enhanced rejuvenating effects on aging muscle and heart.

Cite This Study

Yeşilyurt et al. (2026) studied this question.

synapsesocial.com/papers/69a3d824ec16d51705d2eaf0https://doi.org/10.1113/jp287702
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