What question did this study set out to answer?

To assess the effects of bisphosphonates on bone micro-architecture in children with Duchenne muscular dystrophy.

March 1, 20260 citations

Effects of Bisphosphonates on Bone Micro-Architecture of Children With Duchenne Muscular Dystrophy: A Prospective Comparative Study.

SWSongqi WangChinese Academy of Medical Sciences & Peking Union Medical College YDYi DaiChinese Academy of Medical Sciences & Peking Union Medical College LMLingyang MengChinese Academy of Medical Sciences & Peking Union Medical College

Key Points

To assess the effects of bisphosphonates on bone micro-architecture in children with Duchenne muscular dystrophy.
Conducted a prospective comparative study
Administered zoledronic acid and alendronate to participants
Evaluated changes in bone micro-architecture
Improved bone micro-architecture observed
Increased trabecular bone score (TBS) noted
Enhanced aBMD (areal bone mineral density) recorded

Abstract

This relatively long-term study confirms that zoledronic acid and alendronate are beneficial to improve micro-architecture reflected by TBS and aBMD of children or adolescents with DMD.

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