Retrospective study of fatal and recovered COVID-19 cases in the intensive care unit of Manavgat State Hospital

Objectives: In this study we aimed to describe the clinical features, treatment, and outcomes of patients with COVID-19 admitted to theintensive care unit.Patients and methods: In this retrospective, observational study, we enrolled 116 patients (69 males, 47 females; mean age: 66.9±13.6 years;range, 23 to 93 years) with COVID-19 confirmed by PCR tests who were admitted to Manavgat State Hospital. Demographic data, symptoms, laboratoryfindings, comorbidities, treatment, and outcomes were collected between August 1, 2020, and January 1, 2021. Data were compared between patientswho died and those who survived.Results: A total of 62 patients died, with a 53.4% mortality rate, while 54 recovered. The demographic analysis indicated that mortality forpatients in the older age group (i.e., ≥60 years) was higher than those in the younger age group (84%, 68.5%). In addition, seven laboratoryparameters were statistically associated with mortality: neutrophil (p<0.001), C-reactive protein (p<0.001), urea (p<0.001), lactate dehydrogenase(p<0.001), ferritin (p<0.001), D-dimer (p<0.001), and Troponin-I (p<0.001). Sixty-three patients (55%) required mechanical ventilation, and onlyone patient (2%) survived after mechanical ventilation. The median time from intensive care unit admission to death was 11.5 days (interquartilerange 7.0-17). At 28 days and 60 days, 57 (49%) and four (3.5%) patients died, respectively. On the 72nd day, one (0.9%) patient died.Conclusion: Neutrophil, C-reactive protein, urea, lactate dehydrogenase, ferritin, D-dimer, and Troponin-I counts were found to be predictive of deathin these patients. Further studies are needed to aid efficient recognition and management of severe COVID-19 patients in our population.Keywords: COVID-19, CRP, intensive care units, Manavgat, non-survivors, survivors.