Obesity, a global health epidemic, is closely linked to increased morbidity and mortality. In Ayurveda, it is correlated with Sthaulya, caused by Medo Dhatu Vriddhi (excess fat accumulation) mention in Astonindita Purushaadhaya. This pilot study aimed to compare the therapeutic effects of Brihat Agnimanth (Premna integrifolia Linn.) and Laghu Agnimanth (Clerodendrum phlomidis Linn. f.) mool kwath in managing Sthaulya (obesity). A randomized, parallel clinical trial was conducted on 30 patients aged 18–60 years with BMI ≥25 kg/m². Group A received Brihat Agnimanth mool kwath, and Group B received Laghu Agnimanth mool kwath for 60 days. Anthropometric (weight, BMI, abdominal circumference), clinical (Kshudaadhikya, Pipāsādhikya, Swedādhikya, Daurbalya), and biochemical (cholesterol, triglycerides, LDL, HDL) parameters were assessed statistically. Both groups showed significant intragroup improvements in all parameters. Intergroup analysis revealed no significant difference (p > 0.05) in weight, BMI, or lipid levels, except for HDL cholesterol, where Brihat Agnimanth showed significantly higher improvement (p < 0.05). The findings suggest that both Brihat and Laghu Agnimanth are effective in reducing obesity and improving metabolic health. Brihat Agnimanth demonstrated superior lipid-modulating activity, while Laghu Agnimanth showed slightly better BMI reduction. Both can be considered safe and beneficial Ayurvedic formulations for obesity management.
*1Dr. Rakesh Kumar, 2Dr. Satyender Kumar, 3Dr. Narendra Mehta, 4Dr. Kavita Kumari (Sun,) studied this question.