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March 1, 2026

Postoperative Adjuvant Chemoradiotherapy ± PD-1 Inhibitor for Locally Advanced Head and Neck Squamous Cell Carcinoma.

Zihan Wang Tao Chen Donghui Jiang Sheng Cheng Jingyu Gao Yan Wang Shuai Fu Qing Ying Cui Yanli Yang LV Li Yuchuan Xu Yan Li Rui Tian Chunlei Ge Rongqing Li

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Key Points

To assess the role of PD-1 inhibitors alongside chemoradiotherapy in improving outcomes for head and neck squamous cell carcinoma.
Evaluated treatment outcomes of PD-1 inhibitors in combination with chemoradiotherapy.
Analyzed variations in efficacy based on tumor characteristics.
Compared outcomes in patients receiving only chemoradiotherapy versus those receiving the combination.
PD-1 inhibitors showed less impact on tumors with favorable treatment outcomes.
Patients with better treatment responses from chemoradiotherapy gained fewer benefits from PD-1 inhibitors.

Implication

Investigates the impact of PD-1 inhibitors on treatment outcomes in head and neck cancer, indicating potential limited benefits.

Abstract

PD-1 Ab may contribute less to tumors with better treatment outcomes from concurrent chemoradiotherapy.

Discussion

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Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/69a3d856ec16d51705d2f244 https://doi.org/10.1002/cnr2.70488

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1PD-1 inhibitors combined with induction chemotherapy followed by chemoradiotherapy in HPV-negative locally advanced head and neck squamous cell carcinoma: a real-world studyRetrospective Study · 2026
2Efficacy of PD-1 inhibitor with neoadjuvant chemotherapy in hypopharyngeal and oropharyngeal cancer2024 · 5 citations
3Postoperative Combined Modality Treatment in High Risk Resected Locally Advanced Squamous Cell Carcinomas of the Head and Neck (HNSCC)Original Research · 2018 · 28 citations
4[Phase Ⅱ clinical trial of PD-1 inhibitor combined with chemotherapy for locally advanced resectable oral squamous cell carcinoma].2024 · 5 citations
5Neoadjuvant chemotherapy with/without PD-1i in locally advanced laryngeal/hypopharyngeal cancer: A multicentered retrospective study.Cohort Study · 2026

Perioperative immune checkpoint inhibition in head and neck squamous cell carcinoma: a 10-year review2026
Postoperative adjuvant immunotherapy versus standard of care in resectable locally advanced head and neck squamous cell carcinoma with intermediate- and high-risk factors: a real-world retrospective study2025
Perioperative or adjuvant PD-1/PD-L1 blockade with curative-intent multimodality therapy for locally advanced head and neck squamous cell carcinoma: A systematic review and meta-analysis of randomized trials.2026

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