Detection of OXA-23 and OXA-58 in Proteus mirabilis by immunochromatographic assays

OXA-23 and OXA-58 are among the most frequent carbapenemases in Proteus mirabilis but are often missed because of the difficult detection. In this article, the performance of immunochromatographic assays for the rapid and easy detection of these enzymes is assessed. The study includes a very large set of molecularly well-characterized isolates. The present work demonstrates that the notoriously challenging detection of carbapenemases in P. mirabilis can be achieved by immunochromatographic assays, enabling laboratories outside of academic centers to reliably detect these emerging carbapenemases in a short time. This will help prevent the further spread of carbapenemase-producing P. mirabilis in hospitals.