Comparative Efficacy of Microfluidics and Density Gradient Centrifugation for Sperm Preparation in IVF: A Randomized Controlled Trial.

Key Points

• This research examines the effectiveness of microfluidics compared to density gradient centrifugation for sperm preparation in IVF.
• Conducted a randomized controlled trial
• Compared sperm DNA fragmentation between microfluidics and centrifugation
• Assessed clinical outcomes of IVF using prepared sperm samples
• Microfluidics reduced sperm DNA fragmentation in high DFI samples
• No significant difference in clinical outcomes between preparation methods
• Baseline sperm DNA fragmentation index influenced IVF success rates