Investigates antioxidant and antimutagenic effects of Crataegus monogyna extracts, indicating significant protective properties.
In the present study, we aimed to investigate the genotoxic and anti-genotoxic potencies of fruits of Crataegus monogyna subsp. monogyna (C.M.) by using the micronucleus (MN) and sister chromatide change (SCE) tests in human blood cells. According to the results obtained from the MN and SCE tests, all extracts of C.M. have antimutagenic effect. The most effective extracts were in methanol and acetone. The 40-80 µg/mL doses of C.M. were more effective than other doses. In addition, we evaluated the antioxidant activity in order to clarify the possible mechanisms that may contribute to the anti-genotoxic activity of C.M. Similarly, all extracts displayed antioxidant activity; the most effective extracts were in methanol and acetone. The order of the antigenotoxic and antioxidant effect of the most effective extracts was as follows: CMA (Crataegus monogyna acetone) > CMM (Crataegus monogyna methanol) > CME (Crataegus monogyna ethanol) > CMW (Crataegus monogyna water).
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S. et al. (2020) studied this question.
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