What question did this study set out to answer?

This research aimed to assess the diagnostic utility of NGAL for predicting acute kidney disease following acute kidney injury in STEMI patients.

Neutrophil Gelatinase‐Associated Lipocalin (NGAL) for the Assessment of Persistent Renal Dysfunction after Acute Kidney Injury

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This prospective observational study evaluates NGAL for predicting AKD in STEMI patients, indicating its potential as a biomarker.

This research aimed to assess the diagnostic utility of NGAL for predicting acute kidney disease following acute kidney injury in STEMI patients.
Conducted a prospective observational study with 312 STEMI patients.
Measured NGAL levels within 2 hours of hospital admission.
Defined AKI and AKD using KDIGO criteria and excluded patients with chronic inflammation or end-stage renal disease.
Used ROC analysis to evaluate NGAL's predictive value for AKD.
21% of patients developed AKI, with 47% of those progressing to AKD.
Patients with AKD had significantly higher NGAL levels at admission compared to other groups (p<0.001).
NGAL demonstrated good predictive ability for AKD (AUC of 0.784) with optimal threshold >150 ng/ml.
NGAL >150 ng/ml was identified as an independent predictor of AKD with a hazard ratio of 6.4 (95% CI 1.94-21.06, p<0.001).

Frydman et al. (2026) studied this question.

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View Full Paper

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Authors

This prospective observational study evaluates NGAL for predicting AKD in STEMI patients, indicating its potential as a biomarker.

This research aimed to assess the diagnostic utility of NGAL for predicting acute kidney disease following acute kidney injury in STEMI patients.
Conducted a prospective observational study with 312 STEMI patients.
Measured NGAL levels within 2 hours of hospital admission.
Defined AKI and AKD using KDIGO criteria and excluded patients with chronic inflammation or end-stage renal disease.
Used ROC analysis to evaluate NGAL's predictive value for AKD.
21% of patients developed AKI, with 47% of those progressing to AKD.
Patients with AKD had significantly higher NGAL levels at admission compared to other groups (p<0.001).
NGAL demonstrated good predictive ability for AKD (AUC of 0.784) with optimal threshold >150 ng/ml.
NGAL >150 ng/ml was identified as an independent predictor of AKD with a hazard ratio of 6.4 (95% CI 1.94-21.06, p<0.001).

Frydman et al. (2026) studied this question.

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