What is the clinical evidence from this study?

Study design: Cohort. Population: Sepsis and Acute Kidney Injury (n=46). Intervention: Serum NGAL > 290 µg/l vs. Serum NGAL ≤ 290 µg/l. Primary outcome: Development of acute kidney injury (AKI) (OR 15.9, 95% CI 3.0-85.1, p=0.001).

What does this research mean for the field?

Serum NGAL levels exceeding 290 µg/L on admission day are associated with an approximately 16-fold increase in the risk of acute kidney injury in critically ill patients with sepsis. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

December 31, 2024Physiological ResearchOpen Access

Day 1 serum NGAL >290 µg/l linked to ~16-fold greater AKI risk in sepsis.

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Why the study?

Acute kidney injury is a frequent complication in critically ill septic patients, and new renal biomarkers may aid in early diagnosis.

Does serum NGAL determination predict the development of acute kidney injury in critically ill septic patients?

Population

46 patients (31 with AKI and 15 without AKI on admission)

Comparison

NGAL levels categorized by a cut-off value of 290 µg/l

Key result

Serum NGAL levels greater than 290 µg/l on day 1 were associated with a nearly 16-fold increased risk of developing acute kidney injury in critically ill patients with sepsis (OR 15.9).

Authors

VKViktor Klementa NPNaděžda Petejová JZJosef Zadražil

Discussion

Member takes

Overview

Renal biomarkers may aid early AKI detection; leaves open validation in larger prospective cohorts.

Study Design

Type

Cohort (n=46)

Blinding

Open-label

Multicenter

Yes

Structured PICO

Does serum NGAL determination predict the development of acute kidney injury in critically ill septic patients?

Population

46 critically ill adult patients with sepsis, free of severe chronic kidney disease, followed for 7 days to evaluate serum NGAL as a predictor of acute kidney injury.

Exposure

Serum neutrophil gelatinase-associated lipocalin (NGAL) measurement on the first, fourth, and seventh days of treatment

Outcome

Development of acute kidney injury (AKI)surrogate

Main Result

Odds Ratio: 15.9 (95% CI 3–85.1)

p-value: p=0.001

Serum NGAL levels > 290 µg/l strongly predict the development of acute kidney injury in critically ill septic patients, serving as a useful tool for early detection.

Limitations

Relatively small sample size with potential for bias.
Sepsis enhances plasma NGAL production irrespective of the presence of AKI, which may confound results.
Lack of standardized assays and reference ranges for NGAL measurement across different commercial platforms.
Limited utility in certain populations, such as patients with chronic kidney disease or those on dialysis.

Cite This Study

Klementa et al. (2024) conducted a cohort in Sepsis and Acute Kidney Injury (n=46). Serum NGAL > 290 µg/l vs. Serum NGAL ≤ 290 µg/l was evaluated on Development of acute kidney injury (AKI) (OR 15.9, 95% CI 3.0-85.1, p=0.001). Serum NGAL levels greater than 290 µg/l on day 1 were associated with a nearly 16-fold increased risk of developing acute kidney injury in critically ill patients with sepsis (OR 15.9).

synapsesocial.com/papers/6aa8eb16262dd5f9576bf836 https://doi.org/10.33549/physiolres.935336

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December 31, 2024Physiological ResearchOpen Access

Day 1 serum NGAL >290 µg/l linked to ~16-fold greater AKI risk in sepsis.

View Full Paper

Ask AI

Bookmark

Why the study?

Acute kidney injury is a frequent complication in critically ill septic patients, and new renal biomarkers may aid in early diagnosis.

Does serum NGAL determination predict the development of acute kidney injury in critically ill septic patients?

Population

46 patients (31 with AKI and 15 without AKI on admission)

Comparison

NGAL levels categorized by a cut-off value of 290 µg/l

Key result

Serum NGAL levels greater than 290 µg/l on day 1 were associated with a nearly 16-fold increased risk of developing acute kidney injury in critically ill patients with sepsis (OR 15.9).

Authors

VKViktor Klementa NPNaděžda Petejová JZJosef Zadražil

Discussion

Member takes

Overview

Renal biomarkers may aid early AKI detection; leaves open validation in larger prospective cohorts.

Study Design

Type

Cohort (n=46)

Blinding

Open-label

Multicenter

Yes

Structured PICO

Does serum NGAL determination predict the development of acute kidney injury in critically ill septic patients?

Population

46 critically ill adult patients with sepsis, free of severe chronic kidney disease, followed for 7 days to evaluate serum NGAL as a predictor of acute kidney injury.

Exposure

Serum neutrophil gelatinase-associated lipocalin (NGAL) measurement on the first, fourth, and seventh days of treatment

Outcome

Development of acute kidney injury (AKI)surrogate

Main Result

Odds Ratio: 15.9 (95% CI 3–85.1)

p-value: p=0.001

Serum NGAL levels > 290 µg/l strongly predict the development of acute kidney injury in critically ill septic patients, serving as a useful tool for early detection.

Limitations

Relatively small sample size with potential for bias.
Sepsis enhances plasma NGAL production irrespective of the presence of AKI, which may confound results.
Lack of standardized assays and reference ranges for NGAL measurement across different commercial platforms.
Limited utility in certain populations, such as patients with chronic kidney disease or those on dialysis.

Cite This Study

synapsesocial.com/papers/6aa8eb16262dd5f9576bf836 https://doi.org/10.33549/physiolres.935336

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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