PulseJournal ClubResearchersJournalsExplore
Instagram
HomeJournal ClubExplore
Synapse
⌘+K
Synapse
May 13, 2026Research Journal of Critical Care NephrologyOpen Access

Diagnostic Accuracy of Serum and Urinary Neutrophil Gelatinase-associated Lipocalin for Predicting Sepsis-associated Acute Kidney Injury: A Systematic Review and Meta-Analysis

View Full Paper
Ask AI
Bookmark
Share

Authors

FGFarid Javandoust GharehbaghLLLegha LotfollahiANAmir Ahmad Nassiri

Discussion

Loading...

Member takes

Overview

Systematic review reports diagnostic accuracy of NGAL biomarkers predicting SA-AKI in adults, suggesting potential for early risk stratification.

Key Points

  • This review evaluates the diagnostic accuracy of serum and urinary NGAL for predicting sepsis-associated acute kidney injury in adults.
  • Systematic search of PubMed for studies on serum and urinary NGAL in adults with sepsis
  • Pooled analysis of sensitivity, specificity, and diagnostic odds ratios
  • Subgroup analyses based on clinical setting and timing of biomarker measurement
  • Seventeen studies met inclusion criteria for analysis
  • Serum NGAL sensitivity was 0.77 and specificity 0.68, with an AUC of 0.773
  • Urinary NGAL showed sensitivity of 0.75 and specificity of 0.71, with an AUC of 0.782

Cite This Study

Gharehbagh et al. (2026) studied this question.

synapsesocial.com/papers/6a03cc3d1c527af8f1ed01eahttps://doi.org/10.66224/rjccn.2.02.47
View Full Paper
Ask AI
Bookmark
Share