In vivo disposition research shows sulfation as the main metabolic pathway in rats, indicating significant elimination and moderate bioavailability.
In vivo disposition of Andrographolide was studied in rats. It showed high elimination and moderate bioavailability. 34/39 metabolites were sulfated, making sulfation its main pathway. A novel MS/MS workflow identified 4 sulfation sites.
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Sun et al. (2026) studied this question.
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