September 1, 2013New England Journal of Medicine
Dabigatran versus Warfarin in Patients with Mechanical Heart Valves
Why the study?
Does dabigatran improve outcomes or reduce complications compared to warfarin in patients with mechanical heart valves?
Population
Patients with mechanical heart valves
Comparison
Dabigatran vs Warfarin
Authors
Discussion
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Implication
Dabigatran should not be used in patients with mechanical heart valves due to increased risk of both thromboembolic and bleeding complications compared to standard warfarin therapy.
Structured PICO
Does dabigatran improve outcomes or reduce complications compared to warfarin in patients with mechanical heart valves?
P
Population
Patients with mechanical heart valves
I
Intervention
Dabigatran
C
Comparator
Warfarin
O
Outcome
Thromboembolic and bleeding complicationshard clinical
Dabigatran should not be used in patients with mechanical heart valves due to increased risk of both thromboembolic and bleeding complications compared to standard warfarin therapy.
Cite This Study
Eikelboom et al. (2013) studied this question.