Viewpoint highlights ROCK2 inhibition as an effective strategy for atopic dermatitis using compound 10d in mice, suggesting promising therapeutic potential.
Atopic dermatitis (AD) remains a significant therapeutic challenge. This Viewpoint summarizes the discovery of compound 10d, a natural product-inspired selective ROCK2 inhibitor, whose design was guided by the identification of a novel hydrophobic surface unique to ROCK2. The compound demonstrates compelling efficacy in a mouse model of MC903-induced AD, positioning selective ROCK2 inhibition as a promising strategy for this condition.
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Liu et al. (2026) studied this question.
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