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June 28, 2026Expert Opinion on Therapeutic Targets

The biological role of CCR4 and its ligands CCL17 and CCL22 in atopic dermatitis: therapeutic implications and future directions

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Authors

DDDante DahabrehDPDev PatelEDEster Del Duca

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Overview

Review highlights the role of CCR4, CCL17, and CCL22 in atopic dermatitis, suggesting new therapeutic strategies.

Key Points

  • This review aims to elucidate the role of CCR4 and its ligands in the pathobiology of atopic dermatitis and explore therapeutic opportunities.
  • Reviewed literature on CCR4's role in atopic dermatitis and its signaling pathways.
  • Summarized molecular pharmacology of CCR4 and its endogenous ligands CCL17 and CCL22.
  • Assessed current therapeutic agents targeting CCR4 and their development challenges.
  • Identified CCR4 as a key mediator in Th2 cell migration to inflamed skin in atopic dermatitis.
  • Discussed potential of small-molecule allosteric inhibitors and neutraligands targeting the CCR4 signaling axis.
  • Outlined challenges in the development of CCR4-targeted therapies.

Cite This Study

Dahabreh et al. (2026) studied this question.

synapsesocial.com/papers/6a40b8ed61bb0a67205c572ehttps://doi.org/10.1080/14728222.2026.2690137
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