This meta-analysis demonstrates that PBM has significant therapeutic potential for AD animal models by improving cognition and ameliorating key pathologies. The mechanisms likely involve mitigating oxidative stress and enhancing mitochondrial function. While preclinical evidence strongly supports the efficacy of PBM, translation to humans requires careful optimization of treatment parameters and dose-response relationships. Further high-quality preclinical trials are crucial to validate the therapeutic potential of PBM for AD.
Zhou et al. (Fri,) studied this question.