Longitudinal analysis of viral suppression before, during, and after pregnancy among women on antiretroviral therapy in Uganda: six-year real-world experience.

Q: What does this research mean for the field?

Adherence to antiretroviral therapy (ART) is crucial for optimal maternal outcomes in women living with HIV during pregnancy, with ART effectiveness varying before and after pregnancy. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

Collins Ankunda; Jude Emunyu; Sharon Namasambi; Brendah Kyomuhangi; Conrad Sserunjogi; Iving Mumbere; Jane Nakawesi

doi:10.1080/25787489.2026.2637206

December 31, 2026

Longitudinal analysis of viral suppression before, during, and after pregnancy among women on antiretroviral therapy in Uganda: six-year real-world experience.

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Key Points

The aim is to analyze the effectiveness of antiretroviral therapy on viral suppression during different maternal timelines.
Conducted a longitudinal analysis over six years.
Evaluated viral suppression rates before, during, and after pregnancy.
Compared suppression rates across different ART regimens.
Assessed adherence levels and their impact on outcomes.
Viral suppression showed varying effectiveness before and after pregnancy, but not during.
EFV- and NVP-based regimens achieved comparable suppression rates to DTG.
PI-based regimens had different outcomes.
Good adherence was critical for optimal maternal health outcomes.

Implication

Longitudinal analysis reveals ART effectiveness variances in maternal health, implying adherence matters more than regimens.

Abstract

ART effectiveness showed variation before and after, but not during pregnancy. EFV- and NVP-based regimens achieved suppression rates comparable to DTG across maternal timelines, with the exception of PI-based regimens. Adherence and ART drugs influence outcomes more than regimen choice alone, with good adherence essential for optimal maternal outcomes.

Discussion

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Cite This Study

Ankunda et al. (2026) studied this question.

synapsesocial.com/papers/69a52d9af1e85e5c73bf090d https://doi.org/10.1080/25787489.2026.2637206

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Longitudinal analysis of viral suppression before, during, and after pregnancy among women on antiretroviral therapy in Uganda: six-year real-world experience.

Key Points

Implication

Abstract

Discussion

Cite This Study

Longitudinal analysis of viral suppression before, during, and after pregnancy among women on antiretroviral therapy in Uganda: six-year real-world experience.

Key Points

Implication

Abstract

Discussion

Cite This Study

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