In Silico evaluation of bioactive compounds as potential inhibitors targeting HIF-1 α /VEGFA/BACE1 pathway against Alzheimer’s disease

Key Points

• This research aims to evaluate bioactive compounds that may inhibit the HIF-1α/VEGFA/BACE1 pathway, potentially aiding Alzheimer's treatment.
• In silico screening of bioactive compounds
• Targeting HIF-1α, VEGFA, and BACE1 pathways
• Analysis of molecular interactions and potential efficacy
• Identified promising compounds that may inhibit target pathways
• Suggests potential development of safer, tailored medications
• Highlights the importance of continued validation for effectiveness