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March 2, 2026

The Effect of Capromorelin and Extended-Release Buprenorphine on Body Weight in Guinea Pigs (Cavia porcellus).

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Authors

JSJennifer K SilversSNSarah L. NorrisEPElizabeth M Punger

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Overview

Evaluates capromorelin's effect on weight loss in guinea pigs receiving buprenorphine, suggesting limited impact.

Key Points

  • Evaluate whether capromorelin mitigates weight loss associated with buprenorphine XR in guinea pigs.
  • Randomized 48 guinea pigs into 4 groups (n = 12/group) using a 2 × 2 factorial design.
  • Administered oral capromorelin or sham treatment daily for 3 days alongside buprenorphine XR or saline.
  • Recorded body weights on specified days before and after treatment.
  • Guinea pigs receiving buprenorphine XR lost significant weight compared to controls.
  • Capromorelin treatment did not significantly impact weight change.
  • No interaction was observed between capromorelin and buprenorphine XR.

Cite This Study

Silvers et al. (2026) studied this question.

synapsesocial.com/papers/69a52e34f1e85e5c73bf1a99https://doi.org/10.30802/aalas-jaalas-25-162
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