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The review aims to assess the evolution and current status of peripheral nerve interfaces, specifically for small-diameter nerves.

March 2, 2026Bioelectronic MedicineOpen Access

Scaling beyond the vagus nerve: historical and contemporary progress on electrode-based small-diameter peripheral nerve interfaces

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Review explores historical and modern developments in bioelectronic interfaces, highlighting small nerve challenges and solutions.

The review aims to assess the evolution and current status of peripheral nerve interfaces, specifically for small-diameter nerves.
Examined historical experiments and developments in electrical neuromodulation.
Reviewed FDA-approved and investigational peripheral nerve interfaces.
Highlighted new materials and technologies for targeting small, branched nerves.
Identified limitations in current clinical approaches for peripheral nerve interfacing.
Emphasized the relevance of small-diameter nerve interfaces for new therapies.
Outlined future opportunities for advancements in bioelectronic medicine.

Li et al. (2026) studied this question.

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