What question did this study set out to answer?

To review the current clinical trial landscape and therapeutic status of emerging pharmacological, surgical, and neurostimulation interventions for managing hyperphagia and obesity in Prader-Willi syndrome.

January 21, 2023International Journal of Molecular SciencesOpen Access

Clinical Trials in Prader–Willi Syndrome: A Review

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To review the current clinical trial landscape and therapeutic status of emerging pharmacological, surgical, and neurostimulation interventions for managing hyperphagia and obesity in Prader-Willi syndrome.
Synthesized clinical trial evidence addressing life-threatening hyperphagia and food-related behavioral challenges in individuals with Prader-Willi syndrome across major genetic subtypes.
Evaluated investigational modalities including beloranib, setmelanotide, diazoxide choline controlled-release tablets, unacylated ghrelin analogues, oxytocin-related agents, glucagon-like peptide 1 agonists, bariatric surgery, and transcranial direct-current stimulation.
No approved therapeutics currently exist to manage hyperphagia or prevent life-threatening obesity in individuals with Prader-Willi syndrome.
Multiple ongoing clinical investigations targeting metabolic, neuroendocrine, and neuromodulatory pathways demonstrate varied preliminary progress toward addressing critical unmet behavioral and metabolic needs.

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Implication

Review examines clinical trial interventions for hyperphagia and morbid obesity in Prader-Willi syndrome, highlighting ongoing efforts to address critical unmet therapeutic needs.

Cite This Study

Mahmoud et al. (2023) studied this question.

synapsesocial.com/papers/69a60285900573fd9768c8da https://doi.org/10.3390/ijms24032150

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Implication

Review examines clinical trial interventions for hyperphagia and morbid obesity in Prader-Willi syndrome, highlighting ongoing efforts to address critical unmet therapeutic needs.

Clinical Trials in Prader–Willi Syndrome: A Review

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Discussion

Implication

Cite This Study

Clinical Trials in Prader–Willi Syndrome: A Review

Key Points

Discussion

Implication

Cite This Study

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