A generalizable cross-continent prediction of esophageal squamous cell carcinoma using the oral microbiome

Q: What does this research mean for the field?

The oral microbiome can serve as a non-invasive screening tool for esophageal squamous cell carcinoma (ESCC). Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

Shahd ElNaggar; Wenlong Carl Chen; Leanne Prodehl; Thomas Kekgatleope Marumo; Muhammed U. Khan; Christopher G. Mathew; Paul Ruff; Jin Zhezhen; Alfred I. Neugut; Anil K. Rustgi; Anne-Catrin Uhlemann; Tal Korem; Julian A. Abrams

doi:10.1038/s43856-026-01468-y

February 28, 2026Communications MedicineOpen Access

A generalizable cross-continent prediction of esophageal squamous cell carcinoma using the oral microbiome

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Key Points

The aim is to determine if the oral microbiome can predict esophageal squamous cell carcinoma (ESCC) and serve as a non-invasive screening tool.
Analyzed oral microbiome samples from individuals with ESCC and controls
Compared microbiome profiles to identify distinguishing features
Validated findings across different geographical samples
Identified distinct oral microbiome profiles in individuals with ESCC compared to controls
Demonstrated that these microbiome features generalize across unseen samples
Indicated the potential for saliva to be used as a screening tool for ESCC

Implication

Analysis identifies oral microbiome signals that predict esophageal squamous cell carcinoma, suggesting non-invasive screening potential.

Abstract

Our results show that the oral microbiome in individuals with ESCC is distinct from controls and that this signal can generalize across unseen samples, suggesting the potential of saliva to serve as a non-invasive screening tool for ESCC.

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Cite This Study

ElNaggar et al. (2026) studied this question.

synapsesocial.com/papers/69a67dd6f353c071a6f09cfc https://doi.org/10.1038/s43856-026-01468-y

View Full Paper

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A generalizable cross-continent prediction of esophageal squamous cell carcinoma using the oral microbiome

Key Points

Implication

Abstract

Discussion

Cite This Study

A generalizable cross-continent prediction of esophageal squamous cell carcinoma using the oral microbiome

Key Points

Implication

Abstract

Discussion

Cite This Study

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