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The aim is to improve the immunogenicity of influenza vaccines through a combinatorial DNA vaccine design.

A combinatorial DNA vaccine encoding APC-targeted, bivalent HA and NA antigens results in an improved influenza vaccine

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The aim is to improve the immunogenicity of influenza vaccines through a combinatorial DNA vaccine design.
Designed plasmids encoding hemagglutinin and neuraminidase antigens.
Targeted antigen-presenting cells using secreted vaccine fusion proteins.
Utilized distinct dimerization motifs to maintain antigen separation during delivery.
Induced robust B and T cell responses against both antigens.
Provided increased protection against homologous influenza strains.
Showed enhanced resistance to heterologous H1N1 and H5N1 viruses compared to single-antigen vaccines.

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DNA vaccine enhances immune response in mice, suggesting effectiveness for broader influenza protection.

Werninghaus et al. (2026) studied this question.

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