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This study investigates microRNAs as potential biomarkers to predict chemoresistance in diffuse large B-cell lymphoma.

miR-193-5p, miR-1307-5p, and miR-671-5p: Potential biomarkers for chemoresistance in diffuse large B-cell lymphoma

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Exploratory analysis identifies microRNAs predicting chemoresistance in diffuse large B-cell lymphoma, suggesting early clinical application.

This study investigates microRNAs as potential biomarkers to predict chemoresistance in diffuse large B-cell lymphoma.
Conducted microRNA profiling on 10 diffuse large B-cell lymphoma cases.
Validated differentially expressed miRNAs in 41 retrospectively collected lymphoma biopsies.
Evaluated paired biopsy and plasma samples from 33 cases using qRT-PCR.
Performed functional validation using semi-quantitative proteomics after miRNA knockdown in JM-1 cells.
miR-193b-5p, miR-1307-5p, and miR-671-5p were downregulated in refractory/relapsed cases.
Plasma levels of these miRNAs did not indicate prognosis.
Proteomics analysis showed significant involvement of these miRNAs in key oncogenic pathways.

Sharma et al. (2026) studied this question.

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Exploratory analysis identifies microRNAs predicting chemoresistance in diffuse large B-cell lymphoma, suggesting early clinical application.