Circulating monocytes pre-disposed to form atherogenic foam cells are characterised by distinct transcriptional changes in people with HIV

Key Points

• Foam cell formation is linked to distinct transcriptional changes in circulating monocytes.
• Notable alterations were observed in lipid metabolism pathways related to HIV.
• Assessment of monocyte transcription profiles was conducted in HIV-positive individuals.
• Understanding these changes may help in developing targeted therapies to mitigate cardiovascular risks.