Safety of secondary CRS/HIPEC in peritoneal surface malignancies: Insights from a national cohort study

Key Points

• Secondary CRS/HIPEC shows comparable outcomes to primary CRS/HIPEC in peritoneal surface malignancies.
• Reoperation rates and 30-day mortality rates were similar for both secondary and primary CRS/HIPEC.
• Adjustment for confounding factors maintained the safety profile of secondary CRS/HIPEC.
• Study highlights the feasibility of secondary intervention in selected patients with peritoneal surface malignancies.