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DcR3 reprograms macrophage plasticity to promote wound healing and hair regeneration | Synapse
March 3, 2026
DcR3 reprograms macrophage plasticity to promote wound healing and hair regeneration
SO
Shih-Hsun Ou
YC
Yi-Chun Chen
SH
Shie-Liang Hsieh
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Key Points
Enhanced wound healing and hair regeneration occur with dcR3 modulation of macrophage plasticity, promoting healing in tissues.
Key evidence shows that macrophage reprogramming leads to a significant increase in wound closure rates and hair follicle regeneration.
Assessment using in vitro and in vivo models demonstrates that dcR3 influences cytokine signaling and macrophage behavior directly.
This highlights potential new strategies for therapeutic development in regenerative medicine and skin repair.
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Ou et al. (Sat,) studied this question.
synapsesocial.com/papers/69a75a23c6e9836116a1fb2a
https://doi.org/https://doi.org/10.1016/j.jdermsci.2026.01.002