March 3, 2026Open Access

Melanoma of Unknown Primary Origin: A Case Report and Literature Review

Key Points

Metastatic melanoma can occur without a known primary lesion, posing unique challenges in management.
Recognition of melanoma of unknown primary origin is essential for effective treatment strategies in stage IV cases.
Treatment typically involves systemic therapies similar to those for other metastatic melanoma types, such as immune checkpoint inhibitors.
Standardized management protocols can optimize patient outcomes, indicating the need for prompt intervention.

Abstract

MUP is an uncommon and challenging presentation of metastatic melanoma. Its pathogenesis remains unclear, although several theories, including immune-mediated regression of the primary lesion, have been proposed. MUP should be staged as stage IV disease and treated with the same systemic therapies used for stage IV MKP, including immune checkpoint inhibitors and targeted agents. Prompt recognition and standardized management are crucial to optimizing outcomes in this subset of patients.

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Authors

Matteo Matteucci

Vito D’Andrea

Bruno Cirillo

Journals

Annali Italiani di Chirurgia

Actions

Institutions

University of Milan

Sapienza University of Rome

University of Perugia

References and Citations

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Melanoma of Unknown Primary Origin: A Case Report and Literature Review

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

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