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March 3, 2026International Journal of Biological Macromolecules

All treatments showed marked cardioprotection supported by histology and cardiac biomarkers, with Bacillus protease notably reducing LDH and AST, and vitamin E decreasing BNP, CK-MB, and C-TnI.

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Why the study?

Doxorubicin use is restricted by severe cardiotoxicity, and its acute cardiotoxic effects remain under-investigated regarding histology, cardiac biomarkers, and Wnt/β-catenin signaling modulation by potential cardioprotective agents.

Do Hyphaene Thebaica L. extract, Bacillus-derived proteases, or vitamin E prevent doxorubicin-induced cardiotoxicity in rats?

Population

Forty rats

Comparison

Control vs DOX alone vs DOX co-treated with doum extract, Bacillus protease, or vitamin E

Design

Animal experimental study

Authors

SAShaimaa M. AzzamGSGad Elsayed Mohamed SalemARAmina A.S. Abdel Rahman

Discussion

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Overview

Should not yet change practice in doxorubicin therapy; extends preclinical evidence for natural cardioprotectants.

Key Points

  • Cardiotoxicity was significantly reduced with Hyphaene Thebaica extract and vitamin E, highlighting their potential protective effects.
  • The study shows a modulation of Wnt/β-catenin/GSK3β signaling pathways enhanced by the intervention, underscoring the mechanisms involved.
  • Assessments focused on the impact on cardiac function, revealing that vitamin E combined with Bacillus-derived proteases offers further protective benefits.
  • Findings support the potential of these natural extracts and interventions, promising further development for clinical applications.

Structured PICO

Do Hyphaene Thebaica L. extract, Bacillus-derived proteases, or vitamin E prevent doxorubicin-induced cardiotoxicity in rats?

P
Population
40 rats
I
Intervention
Hyphaene Thebaica L. (Doum) extract, Bacillus-derived proteases (Bp), or vitamin E co-administered with doxorubicin
C
Comparator
Control (no treatment) and doxorubicin alone
O
Outcome
Cardiotoxicity characterized by histological alterations, cardiac biomarkers (AST, LDH, C-TnI, CK-MB, BNP), and Wnt/β-catenin signaling pathway modulationsurrogate

Natural agents including Doum extract, Bacillus protease, and vitamin E mitigate doxorubicin-induced cardiotoxicity in rats by modulating the Wnt/β-catenin signaling pathway.

Cite This Study

Azzam et al. (2026) studied this question.

synapsesocial.com/papers/69a75accc6e9836116a21173https://doi.org/10.1016/j.ijbiomac.2026.150571
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cinnamic Acid Derivatives as Cardioprotective Agents against Oxidative and Structural Damage Induced by Doxorubicin2021 · 29 citations
  2. 2Quercetin-induced cardioprotection against doxorubicin cytotoxicity2013 · 82 citations
  3. 3Protective effects of protocatechuic acid against doxorubicin- and arsenic trioxide-induced toxicity in cardiomyocytes2023 · 15 citations
  4. 4Wnt/β-catenin pathway in arrhythmogenic cardiomyopathy2017 · 65 citations
  5. 5Phosphorylation of Eukaryotic Translation Initiation Factor 2Bε by Glycogen Synthase Kinase-3β Regulates β-Adrenergic Cardiac Myocyte Hypertrophy2004 · 89 citations