Phase II multicentre double-blind randomised controlled trial of a Bivalent VaccInation against Salmonella Typhi and Paratyphi A (BiVISTA) using a controlled human infection model of paratyphoid A infection: study protocol

Margarete Paganotti Vicentine; Naina McCann; Oisin Hennigan; Noshi Maria; Claudia I Juarez Molina; Stanislava Koleva; Mohammod K Islam; Elizabeth Jones; Amy Flaxman; Nicole Day; Allison MacDonald; Mehreen Adnan; Nisha Singh; Sophie Vernon; Eleanor Wilson; Anirudha Vyankatesh Potey; Abhijeet Dharmadhikari; Sanket Gaidhane; Prasad S Kulkarni; Hannah Robinson; Parvinder Aley; Young Chan Kim; Brian Angus; Xinxue Liu; Maheshi Nirmala Ramasamy; Andrew J Pollard

doi:10.1136/bmjopen-2025-107608

Key Points

Bivalent vaccination aims to protect against both Salmonella typhi and paratyphi A infections, enhancing public health.
The trial uses a controlled human infection model to assess the vaccine's effectiveness on induced infections.
Randomised controlled trial protocol involves multiple centers to ensure diverse participant recruitment and reliability of results.
The findings may highlight new strategies for preventing paratyphoid fever, potentially beneficial on a global scale.

No abstract yet

We only have this paper's title and publication details.

Read it at the source

Implication

A phase II trial aims to evaluate a bivalent vaccination against Salmonella in healthy adults, suggesting potential advancements in vaccine effectiveness.

Abstract

Isrctn65855590.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Vicentine et al. (2026) studied this question.

synapsesocial.com/papers/69a75b10c6e9836116a21b3b https://doi.org/10.1136/bmjopen-2025-107608

View Full Paper

Ask AI

Bookmark

Share

Phase II multicentre double-blind randomised controlled trial of a Bivalent VaccInation against Salmonella Typhi and Paratyphi A (BiVISTA) using a controlled human infection model of paratyphoid A infection: study protocol

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

Phase II multicentre double-blind randomised controlled trial of a Bivalent VaccInation against Salmonella Typhi and Paratyphi A (BiVISTA) using a controlled human infection model of paratyphoid A infection: study protocol

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading