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Observational analysis reports malignant progression of fibrous meningioma in a child, suggesting a link to CHEK2 mutations.
Constitutional CHEK2 mutations combined with somatic NF1 defect may have promoted the malignant progression of SEGA-imitating fibrous meningioma and its favorable initial response to mTOR inhibitors.
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Szmyd et al. (2026) studied this question.
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