GTX-11 attenuates lung fibrosis, inflammation and vascular remodeling in preclinical models of lung fibrotic disease

Ana Montes-Worboys; Javier Milara; Consol Farrera; Cristina Fernández-Asensio; Silvia Sánchez-Díez; Jaume Mercadé; Paula Montero; Inés Roger; María Molina-Molina; Eugènia Ruiz-Cánovas; Julio Cortijo

doi:10.3389/fphar.2025.1671132

January 27, 2026Frontiers in PharmacologyOpen Access

GTX-11 attenuates lung fibrosis, inflammation and vascular remodeling in preclinical models of lung fibrotic disease

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Key Points

GTX-11 effectively attenuates lung fibrosis and inflammation, indicating a potential for treatment.
In models, GTX-11 demonstrates antifibrotic activity both in vivo and in vitro, showcasing its versatility.
The analysis involves preclinical models to evaluate the impact of GTX-11 on lung conditions.
These findings suggest GTX-11 may serve as a promising therapeutic option for fibrotic lung diseases.

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Implication

Observational analysis reveals GTX-11 reduces fibrosis and inflammation in preclinical models, suggesting its therapeutic promise.

Abstract

Altogether, our studies reveal that GTX-11 is an effective antifibrotic both in vivo and in vitro, suggesting that GTX-11 has potential as a therapeutic option for fibrotic ILDs.

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Montes-Worboys et al. (2026) studied this question.

synapsesocial.com/papers/69a75b3bc6e9836116a2232f https://doi.org/10.3389/fphar.2025.1671132

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GTX-11 attenuates lung fibrosis, inflammation and vascular remodeling in preclinical models of lung fibrotic disease

Key Points

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Implication

Abstract

Discussion

Cite This Study

GTX-11 attenuates lung fibrosis, inflammation and vascular remodeling in preclinical models of lung fibrotic disease

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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