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Observational analysis reveals storage at -80 °C preserves biomarker stability in cerebrospinal fluid, highlighting critical protocols for diagnostics.
CSF biomarkers NSE and S100 are highly susceptible to degradation at -20 °C, whereas B2M remains relatively stable. Strict adherence to -80 °C storage protocols is essential to ensure the reliability of biomarker-based diagnostics and research.
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García-Sancha et al. (2026) studied this question.
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