Effect of storage conditions on NSE, S100, and B2M stability in cerebrospinal fluid and serum

Key Points

• NSE and S100 biomarkers are significantly degraded at -20 °C, impacting reliability.
• B2M demonstrates relative stability compared to NSE and S100 under various storage conditions.
• Storage protocols at -80 °C are critical for maintaining biomarker integrity over time.
• Proper storage can enhance the accuracy and reliability of cerebrospinal fluid diagnostics.