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March 3, 2026Frontiers in Oncology1 citationsOpen Access

Assessing venous thromboembolism risk in lung cancer: a comprehensive evaluation of the khorana score, clinical characteristics, and incidence of thrombosis

SDSean C. DoughertyRSRishika SinghCMCaleb McKinney

Key Points

  • Development of venous thromboembolism (VTE) risk is not accurately predicted by the Khorana Risk Score (KRS).
  • Clinical characteristics identified include multiple risk factors associated with VTE in both non-small cell and small cell lung cancer.

Structured PICO

Does the Khorana Risk Score accurately predict the risk of venous thromboembolism in patients with NSCLC and SCLC?

P
Population
Patients with non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC)
I
Intervention
Khorana Risk Score (KRS) assessment and clinical characteristics evaluation
O
Outcome
Incidence of venous thromboembolism (VTE)hard clinical

The Khorana Risk Score is insufficient on its own for predicting VTE in lung cancer patients, highlighting the need for updated risk stratification tools that incorporate additional clinical parameters.

Abstract

This study highlights the limitations of the KRS in predicting risk of development of VTE in patients with NSCLC and SCLC and identifies multiple clinical parameters associated with increased risk of VTE. Development of further risk stratification tools incorporating these clinical factors in addition to those in the KRS should be considered.

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Cite This Study

Dougherty et al. (2026) studied this question.

synapsesocial.com/papers/69a75b59c6e9836116a2289dhttps://doi.org/10.3389/fonc.2025.1651192
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prognosis of Cancers Associated with Venous Thromboembolism2000 · 1,644 citations
  2. 2Validation of the Caprini Venous Thromboembolism Risk Assessment Model in Critically Ill Surgical Patients2015 · 188 citations
  3. 3Morbidity, mortality and costs associated with venous thromboembolism in hospitalized patients with cancer2018 · 197 citations
  4. 4A risk assessment model for the identification of hospitalized medical patients at risk for venous thromboembolism: the Padua Prediction Score2010 · 1,251 citations
  5. 5Thromboembolic risk in patients with lung cancer receiving systemic therapy2021 · 17 citations