Paracetamol versus ibuprofen as required for fever or pain in the first year of life and the risk of eczema and bronchiolitis at age 1 year in New Zealand (PIPPA Tamariki): a multicentre, open-label, parallel-group, superiority, randomised controlled trial | Synapse
March 3, 2026
Paracetamol versus ibuprofen as required for fever or pain in the first year of life and the risk of eczema and bronchiolitis at age 1 year in New Zealand (PIPPA Tamariki): a multicentre, open-label, parallel-group, superiority, randomised controlled trial
Key Points
Eczema and bronchiolitis risks were assessed at one year of age in infants using paracetamol or ibuprofen.
The trial involved multiple centers in New Zealand, enhancing diversity and applicability of findings.
A total of 314 infants were recruited for this open-label, parallel-group trial, focusing on safety and effectiveness.
Implications suggest potential differences in the incidence of eczema and bronchiolitis related to the choice between paracetamol and ibuprofen.