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Comparison reveals semiology similarities in spontaneous and stimulation-induced seizures in epilepsy, suggesting clinical implications.
This study reports on semiology (clinical symptoms and signs of seizures) in people with epilepsy undergoing in-depth brain exploration for presurgical evaluation. It compares the semiology in seizures occurring spontaneously with the semiology in seizures triggered by direct cortical stimulation. Semiologic similarity was high between spontaneous and stimulation-induced seizures. Atypical seizures triggered by stimulation were fairly rare. Atypical seizures may occur in conditions of altered stimulation threshold. Some patients experienced past seizure semiology reactivated by cortical stimulation.
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Mahizhnan et al. (2026) studied this question.
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