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Cytoplasm-nucleus shuttling of TET2: an intrinsic brake in colorectal cancer progression | Synapse
March 3, 2026
Open Access
Cytoplasm-nucleus shuttling of TET2: an intrinsic brake in colorectal cancer progression
CL
Changpeng Li
FM
Fei Meng
Shenyang Medical College
JH
Jingcai He
Jinan University
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Key Points
Tumor progression is slowed by the cytoplasm-nucleus shuttling of TET2 in colorectal cancer.
Notably, decreased TET2 in colorectal cancer cells correlates with enhanced tumor growth.
Analysis involves examining TET2's role within cellular compartments in cancer cells.
Discoveries highlight the potential for targeting TET2 in colorectal cancer therapeutics.
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Li et al. (Wed,) studied this question.
synapsesocial.com/papers/69a75c0fc6e9836116a2478b
https://doi.org/https://doi.org/10.1038/s41419-026-08418-5