A type I interferon-mitochondrial axis regulates efferocytosis and interferon-stimulated gene induction in macrophages

Key Points

• Efferocytosis is significantly regulated by type I interferon, enhancing macrophage functions.
• Increased expression of interferon-stimulated genes was observed in macrophages under specific conditions.
• This analysis uses a novel approach to explore cellular interactions involving mitochondria and immune cells.
• Understanding this axis may uncover therapeutic targets for enhancing immune response, particularly in inflammatory diseases.